Combination of LED light and platelet‐derived growth factor to accelerate dentoalveolar osteogenesis. (15th September 2014)

• Record Type: Journal Article
• Authors: Chang, Po‐Chun; Wang, Chen‐Ying; Sheng‐Chueh, Tsai
• Is Part Of: Journal of clinical periodontology. Volume 41:Number 10(2014:Oct.)
• Page Start: 999
• Page End: 1006
• Publication Date: 2014-09-15
• Subjects: Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.12301
• Languages: English
• ISSNs: 0303-6979

Abstract

<abstract abstract-type="main" id="jcpe12301-abs-0001"> <title>Abstract</title> <sec id="jcpe12301-sec-0001" sec-type="section"> <title>Aim</title> <p>This study aimed to evaluate the adjunctive effect of LED light in platelet‐derived growth factor (PDGF)‐aided dentoalveolar osteogenesis.</p> </sec> <sec id="jcpe12301-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>Full‐thickness osseous wounds were created on rat maxillae and were either unfilled or filled with poly‐(D, L‐lactide) and poly‐(D, L‐lactide‐co‐glycolide) microspheres encapsulating PDGF. Animals received daily 660 ± 25 nm LED light irradiation at 0, 10 (LD), or 20 (HD) J/cm<sup>2</sup>, were killed at days 4–28 (<italic>n</italic> = 6/group/time) and evaluated by microcomputed tomography (micro‐CT), histology, and the expressions of osteopontin and tartrate‐resistant acid phosphatase (TRAP).</p> </sec> <sec id="jcpe12301-sec-0003" sec-type="section"> <title>Results</title> <p>Greater osteogenesis was noted in the PDGF‐treated defects at day 14. Under the LED light irradiation, osteogenesis was significantly greater in both LD and HD groups of the non‐PDGF‐treated defects, but only in the LD group of the PDGF‐treated defects. No significant differences in osteogenesis among groups were noted at day 28. Greater bone marrow space was noted in the LED light‐irradiated specimens, especially in the PDGF‐treated defects at both time points. Osteopontin was significantly promoted in the LD group at both time points, and TRAP was significantly promoted in all LED light‐irradiated groups at day 28.</p> </sec> <sec id="jcpe12301-sec-0004" sec-type="section"> <title>Conclusion</title> <p>LED light could an adjunct to promote early PDGF‐aided dentoalveolar osteogenesis by facilitating the osteoblast–osteoclast coupling.</p> </sec> </abstract>