Relationship between the interleukin‐6‐174 gene and mannose‐binding lectin codon 54 gene polymorphisms and condyloma acuminatum. (3rd October 2013)

• Record Type: Journal Article
• Authors: Aydogan, K.; Ozakin, C.; Saricaoglu, H.; Sigirli, D.; Oral, B.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 28:Number 10(2014:Oct.)
• Page Start: 1306
• Page End: 1312
• Publication Date: 2013-10-03
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.12273
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" id="jdv12273-abs-0001"> <title>Abstract</title> <sec id="jdv12273-sec-0001" sec-type="section"> <title>Background</title> <p>Several genes encoding different Th1 and Th2 cytokines may play crucial roles in host susceptibility to Condyloma acuminatum (CA). Mannose‐binding lectin (MBL) is a serum lectin that mediates complement activation, and it is a member of innate immune system. MBL gene polymorphisms are considered to be associated with several infectious diseases.</p> </sec> <sec id="jdv12273-sec-0002" sec-type="section"> <title>Objective</title> <p>In this study, we investigated the association between cytokines and MBL gene polymorphisms with CA.</p> </sec> <sec id="jdv12273-sec-0003" sec-type="section"> <title>Methods</title> <p>Forty patients with CA and 40 healthy controls were enrolled in this study. These patients had not responded to at least a therapy modality and all patients had recurrent lesions. Polymorphism of cytokine [Th1 cytokines; tumour necrosis factor‐α and interferon (IFN)‐γ, Th2 cytokine; IL‐6, T regulatory/suppressor cytokines; IL‐10 and transforming growth factor‐β] genes studies were performed by Polymerase chain reaction sequence‐specific primers method and MBL genotyping were studied by PCR‐restriction fragment length polymorphism method.</p> </sec> <sec id="jdv12273-sec-0004" sec-type="section"> <title>Results</title> <p>With the aid of agglomerative hierarchical cluster analysis, we categorized subjects into two main clusters (cluster 1; formed by the majority of patients with CA, cluster 2; formed by the majority of healthy controls), which were found to have significantly different distributions of IL‐6 and MBL genotypes. Frequencies of IL‐6 (‐174) G/G (<italic>P</italic> < 0.001) and MBL AA (<italic>P</italic> < 0.001) polymorphisms were significantly greater in the cluster 1. In contrast, significantly lower frequencies of the IL‐6 G/C (<italic>P</italic> = 0.046) genotype and MBL AB (<italic>P</italic> < 0.001) genotype were observed in cluster 1.</p> </sec> <sec id="jdv12273-sec-0005" sec-type="section"> <title>Conclusion</title> <p>These results suggest that the IL‐6 G/G and MBL AA gene polymorphisms are potential risk factors and that the IL‐6 G/C and MBL AB polymorphisms are a protective factor for occurrence and recurrence of CA.</p> </sec> </abstract>