O‐Acyl isopeptide method: development of an O‐acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1‐42 isopeptide. (28th May 2014)

• Record Type: Journal Article
• Authors: Yoshiya, Taku; Uemura, Tsuyoshi; Maruno, Takahiro; Kubo, Shigeru; Kiso, Yoshiaki; Sohma, Youhei; Kobayashi, Yuji; Yoshizawa‐Kumagaye, Kumiko; Nishiuchi, Yuji
• Is Part Of: Journal of peptide science. Volume 20:Number 9(2014:Sep.)
• Page Start: 669
• Page End: 674
• Publication Date: 2014-05-28
• Subjects: Peptides -- Periodicals; Peptides -- Periodicals; 572.65
• DOI: 10.1002/psc.2662
• Languages: English
• ISSNs: 1075-2617

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The <italic>O</italic>‐acyl isopeptide method was developed for the efficient preparation of difficult sequence‐containing peptide. Furthermore, development of the <italic>O</italic>‐acyl isodipeptide unit for Fmoc chemistry simplified its synthetic procedure by solid‐phase peptide synthesis. Here, we report a novel isodipeptide unit for Boc chemistry, and the unit was successfully applied to the synthesis of amyloid <italic>β</italic> peptide. Combination of Boc chemistry and the isodipeptide unit would be an effective method for the synthesis of many difficult peptides. Copyright © 2014 European Peptide Society and John Wiley &amp; Sons, Ltd.</p> </abstract>