Age‐related differences in urinary 11‐dehydroxythromboxane B2 between infants, children, and adolescents: Another example of developmental hemostasis?. Issue 11 (7th May 2014)

• Record Type: Journal Article
• Authors: Varnell, Charles D.; Goldstein, Stuart L.; Yee, Donald L.; Teruya, Jun; Guyer, Kirk E.; Siddiqui, Shakeel; Jefferies, John L.
• Is Part Of: Pediatric blood & cancer. Volume 61:Issue 11(2014:Nov.)
• Page Start: 2074
• Page End: 2076
• Publication Date: 2014-05-07
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25089
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pbc25089-sec-0001" sec-type="section"> <p>Our study was developed to ascertain reference ranges of 11‐dehydrothromboxane B2 (11‐dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11‐dehydrothromboxane B₂. 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11‐dehydrothromboxane B2 (<italic>P</italic> = 0.0001). This study confirms a negative correlation between age and level of urinary 11‐dehydrothromboxane B2 and provides a set of age‐specific reference ranges. Pediatr Blood Cancer 2014;61:2074–2076. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>