Salivary gland carcinomas in children and adolescents: The Italian TREP project experience. Issue 11 (17th August 2014)

• Record Type: Journal Article
• Authors: Chiaravalli, Stefano; Guzzo, Marco; Bisogno, Gianni; De Pasquale, Maria Debora; Migliorati, Roberta; De Leonardis, Francesco; Collini, Paola; Casanova, Michela; Cecchetto, Giovanni; Ferrari, Andrea
• Is Part Of: Pediatric blood & cancer. Volume 61:Issue 11(2014:Nov.)
• Page Start: 1961
• Page End: 1968
• Publication Date: 2014-08-17
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25139
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pbc25139-sec-0001" sec-type="section"> <title>Background</title> <p>Salivary gland carcinomas are extremely rare in pediatric age. We report the clinical features of a series of children/adolescents with salivary gland carcinomas prospectively registered in the Italian TREP (Rare Tumors in Pediatric Age) project.</p> </sec> <sec id="pbc25139-sec-0002" sec-type="section"> <title>Procedures</title> <p>Diagnostic/therapeutic guidelines were developed and shared among Italian pediatric oncology/surgical centers.</p> </sec> <sec id="pbc25139-sec-0003" sec-type="section"> <title>Results</title> <p>Seventeen patients were registered between 2000 and 2012, representing 19% of the cases expected to be seen based on epidemiological data. Tumors arose mainly in the parotid gland (14 cases). In most cases they were low‐grade tumors (14 cases), often with a favorable clinical presentation, and low‐stage disease. All patients underwent surgical resection, achieving histologically free margins in 9/17 cases. Thirteen of the 14 patients with parotid gland tumors had parotidectomy (10 total, 3 superficial), while one had a tumorectomy. Postoperative facial nerve lesions were reported in two cases. Adjuvant radiotherapy was given to 6 patients. The overall prognosis was good: only one patient with a huge high‐grade tumor experienced disease progression and died of the disease. The other 16 patients were alive in first continuous remission 1–8 years after diagnosis. In 4/17 cases, the salivary gland carcinoma was a second tumor occurring 6–9 years after another primary cancer.</p> </sec> <sec id="pbc25139-sec-0004" sec-type="section"> <title>Conclusions</title> <p>This is the first reported prospective national cooperative series of pediatric salivary gland carcinoma patients. Compliance with the TREP recommendations was high. These tumors are rarely managed by pediatric oncologists/surgeons. A broader international cooperation and better networking with otolaryngologists and head‐neck surgeons expert on adult salivary gland carcinomas would be advisable. Pediatr Blood Cancer 2014;61:1961–1968. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>