Maternal hypertriglyceridemia: A link between maternal overweight‐obesity and macrosomia in gestational diabetes. (23rd June 2014)

• Record Type: Journal Article
• Authors: Olmos, Pablo R.; Rigotti, Attilio; Busso, Dolores; Berkowitz, Loni; Santos, José L.; Borzone, Gisella R.; Poblete, José A.; Vera, Claudio; Belmar, Cristián; Goldenberg, Denisse; Samith, Bárbara; Acosta, Ana M.; Escalona, Manuel; Niklitschek, Ian; Mandiola, Jorge R.; Mertens, Nicolás
• Is Part Of: Obesity. Volume 22:Number 10(2014:Oct.)
• Page Start: 2156
• Page End: 2163
• Publication Date: 2014-06-23
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20816
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20816-sec-0001" sec-type="section"> <title>Objective</title> <p>Infants born from overweight and obese mothers with glucose‐controlled gestational diabetes (GDM) tend to be large‐for‐gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels.</p> </sec> <sec id="oby20816-sec-0002" sec-type="section"> <title>Methods</title> <p>Two‐hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20–24.9; <italic>n</italic> = 128), overweight (BMI = 25–29.9; <italic>n</italic> = 105), and obese (BMI ≥ 30; <italic>n</italic> = 46). Individual <italic>z</italic>‐scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean <italic>z</italic>‐scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD.</p> </sec> <sec id="oby20816-sec-0003" sec-type="section"> <title>Results</title> <p>In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (<italic>P</italic> = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (<italic>R</italic><sub>SPEARMAN</sub> = 0.111, <italic>P</italic> = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (<italic>P</italic> = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (<italic>R</italic><sub>SPEARMAN</sub>= 0.116, <italic>P</italic> = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: <italic>r</italic> = 0.12 (<italic>P</italic> = NS), <italic>r</italic> = 0.42 (<italic>P</italic> <0.001), and <italic>r</italic> = 0.47 (<italic>P</italic> < 0.001).</p> </sec> <sec id="oby20816-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.</p> </sec> </abstract>