Dopaminergic agents and nutritional status in Parkinson's disease. Issue 12 (12th September 2014)

• Record Type: Journal Article
• Authors: Laudisio, Alice; Vetrano, Davide L.; Meloni, Eleonora; Ricciardi, Diego; Franceschi, Francesco; Bentivoglio, Anna Rita; Bernabei, Roberto; Zuccalà, Giuseppe
• Is Part Of: Movement disorders. Volume 29:Issue 12(2014)
• Page Start: 1543
• Page End: 1547
• Publication Date: 2014-09-12
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25991
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="mds25991-sec-0001" sec-type="section"> <title>Background</title> <p>Malnutrition has been found in up to 24% of patients with Parkinson's disease; dopaminergic drugs might impair nutritional status. We evaluated the association of nutritional status with the use of dopaminergic agents.</p> </sec> <sec id="mds25991-sec-0002" sec-type="section"> <title>Methods</title> <p>We analyzed data from 75 elderly patients with Parkinson's disease attending a geriatric day hospital. Nutritional status was assessed by the Mini Nutritional Assessment (MNA). Dopaminergic drugs were normalized for weight.</p> </sec> <sec id="mds25991-sec-0003" sec-type="section"> <title>Results</title> <p>In linear regression, total levodopa (<sc>l</sc>‐dopa) equivalent daily dose (LEDD) was associated with worse MNA (B = −0.14, 95% CI = −0.26‐−0.02; <italic>P</italic> = 0.019). This association remained significant only for <sc>l</sc>‐dopa (B = −0.19, 95% CI = −0.32‐−0.52; <italic>P</italic> = 0.007), but not dopaminergic agent dosages. Increasing <sc>l</sc>‐dopa dosages were associated with increasing probability of risk of malnutrition (<italic>P</italic> for trend = 0.049).</p> </sec> <sec id="mds25991-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In our population, LEDD was associated with worse nutritional status and risk of malnutrition; this association was limited to use of <sc>l</sc>‐dopa. © 2014 International Parkinson and Movement Disorder Society</p> </sec> </abstract>