Metal‐Free 2, 3‐Dichloro‐5, 6‐dicyano‐1, 4‐benzoquinone (DDQ)‐Mediated Cross‐Dehydrogenative‐Coupling (CDC) of Benzylic C(sp3)H Bonds and Vinylic C(sp2)H Bonds: Efficient One‐Pot Synthesis of 1H‐Indenes. Issue 14 (21st September 2014)

• Record Type: Journal Article
• Authors: Wang, He; Zhao, Yu‐Long; Li, Lei; Li, Sha‐Sha; Liu, Qun
• Is Part Of: Advanced synthesis & catalysis. Volume 356:Issue 14/15(2014)
• Page Start: 3157
• Page End: 3163
• Publication Date: 2014-09-21
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201400357
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A novel 2, 3‐dichloro‐5, 6‐dicyano‐1, 4‐benzoquinone (DDQ)‐promoted intermolecular cross‐dehydrogenative coupling reaction of alkyl C(<italic>sp</italic>³)H bonds not adjacent to heteroatoms with vinylic C(<italic>sp</italic>²)H bonds has been developed. This new strategy provides a new, environmentally friendly, and efficient protocol for the synthesis of polysubstituted 1<italic>H</italic>‐indenes in a single step <italic>via</italic> a radical‐initiated two C(<italic>sp</italic>²)C(<italic>sp</italic>²) and C(<italic>sp</italic>²)C(<italic>sp</italic>³) bond formation process.</p> <p> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh1fbrph3n" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>