Risk factors for adult‐onset recurrent respiratory papillomatosis. (10th June 2014)

• Record Type: Journal Article
• Authors: Ruiz, Ryan; Achlatis, Stratos; Verma, Avanti; Born, Hayley; Kapadia, Farzana; Fang, Yixin; Pitman, Michael; Sulica, Lucian; Branski, Ryan C.; Amin, Milan R.
• Is Part Of: Laryngoscope. Volume 124:Number 10(2014:Oct.)
• Page Start: 2338
• Page End: 2344
• Publication Date: 2014-06-10
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.24730
• Languages: English
• ISSNs: 0023-852X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="lary24730-sec-0001" sec-type="section"> <title>Objectives/Hypothesis</title> <p>To evaluate risk factors strongly associated with adult‐onset recurrent respiratory papillomatosis (AO‐RRP).</p> </sec> <sec id="lary24730-sec-0002" sec-type="section"> <title>Study Design</title> <p>Prospective, age‐ and sex‐matched, case control.</p> </sec> <sec id="lary24730-sec-0003" sec-type="section"> <title>Methods</title> <p>Patients with AO‐RRP and controls completed a computer‐based, 89‐item questionnaire across three academic institutions.</p> </sec> <sec id="lary24730-sec-0004" sec-type="section"> <title>Results</title> <p>Forty‐eight AO‐RRP patients were compared to 73 controls; 43 of the 48 AO‐RRP patients were male (89.5%). The difference in the median number of lifetime sexual partners between AO‐RRP (15) and controls (10) was significant (<italic>P</italic> = 0.0387). Additionally, an increased number of lifetime sexual partners (≥ 26) was associated with AO‐RRP. No significant difference for the number of lifetime oral sex partners was observed between groups. Increased comorbidity, as quantified by the Charlson Comorbidity Index, was observed in patients with AO‐RRP. AO‐RRP and control groups were similar across many other variables, including birth history, smoking history, alcohol use, drug use, education, income, and the Short Form Health Survey scores.</p> </sec> <sec id="lary24730-sec-0005" sec-type="section"> <title>Conclusions</title> <p>AO‐RRP was not associated with previously proposed risk factors for juvenile‐onset RRP and may be associated with an increased number of lifetime sexual partners.</p> </sec> <sec id="lary24730-sec-0006" sec-type="section"> <title>Level of Evidence</title> <p>3b. <italic>Laryngoscope</italic> 124:2338–2344, 2014</p> </sec> </abstract>