Development and Characterization of a Novel, Antimicrobial, Sterile Hydrogel Dressing for Burn Wounds: Single‐Step Production with Gamma Irradiation Creates Silver Nanoparticles and Radical Polymerization. Issue 10 (30th July 2014)

• Record Type: Journal Article
• Authors: Boonkaew, Benjawan; Barber, Philip M.; Rengpipat, Sirirat; Supaphol, Pitt; Kempf, Margit; He, Jibao; John, Vijay T.; Cuttle, Leila
• Is Part Of: Journal of pharmaceutical sciences. Volume 103:Issue 10(2014:Oct.)
• Page Start: 3244
• Page End: 3253
• Publication Date: 2014-07-30
• Subjects: Pharmacy -- Periodicals; 615.1
• DOI: 10.1002/jps.24095
• Languages: English
• ISSNs: 0022-3549

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound dressing that contains silver nanoparticles (SNPs) to treat infection in a 2‐acrylamido‐2‐methylpropane sulfonic acid sodium salt (AMPS‐Na<sup>+</sup>) hydrogel. Silver nitrate was dissolved in AMPS‐Na<sup>+</sup> solution and then exposed to gamma irradiation to form SNP‐infused hydrogels. The gamma irradiation results in a cross‐linked polymeric network of sterile hydrogel dressing and a reduction of silver ions to form SNPs infused in the hydrogel in a one‐step process. About 80% of the total silver was released from the hydrogels after 72 h immersion in simulated body fluid solution; therefore, they could be used on wounds for up to 3 days. All the hydrogels were found to be nontoxic to normal human dermal fibroblast cells. The silver‐loaded hydrogels had good inhibitory action against <italic>Pseudomonas aeruginosa</italic> and methicillin‐resistant <italic>Staphylococcus aureus</italic>. Results from a pilot study on a porcine burn model showed that the 5‐mM silver hydrogel was efficient at preventing bacterial colonization of wounds, and the results were comparable to the commercially available silver dressings (Acticoat<sup>TM</sup>, PolyMem Silver<sup>®</sup>). These results support its use as a potential burn wound dressing. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3244–3253, 2014</p> </abstract>