Raman spectroscopic evidence of tissue restructuring in heat‐induced tissue fusion. Issue 9 (15th November 2013)

• Record Type: Journal Article
• Authors: Su, Lei; Cloyd, Kristy L.; Arya, Shobhit; Hedegaard, Martin A. B.; Steele, Joseph A. M.; Elson, Daniel S.; Stevens, Molly M.; Hanna, George B.
• Is Part Of: Journal of biophotonics. Volume 7:Issue 9(2014)
• Page Start: 713
• Page End: 723
• Publication Date: 2013-11-15
• Subjects: Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201300099
• Languages: English
• ISSNs: 1864-063X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Heat‐induced tissue fusion via radio‐frequency (RF) energy has gained wide acceptance clinically and here we present the first optical‐Raman‐spectroscopy study on tissue fusion samples <italic>in vitro</italic>. This study provides direct insights into tissue constituent and structural changes on the molecular level, exposing spectroscopic evidence for the loss of distinct collagen fibre rich tissue layers as well as the denaturing and restructuring of collagen crosslinks post RF fusion. These findings open the door for more advanced optical feedback‐control methods and characterization during heat‐induced tissue fusion, which will lead to new clinical applications of this promising technology. (© 2014 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)</p> </abstract>