Concordance between 99mTc‐ECD SPECT and 18F‐FDG PET interpretations in patients with cognitive disorders diagnosed according to NIA‐AA criteria. (29th March 2014)

• Record Type: Journal Article
• Authors: Ito, Kimiteru; Shimano, Yasumasa; Imabayashi, Etsuko; Nakata, Yasuhiro; Omachi, Yoshie; Sato, Noriko; Arima, Kunimasa; Matsuda, Hiroshi
• Is Part Of: International journal of geriatric psychiatry. Volume 29:Number 10(2014:Oct.)
• Page Start: 1079
• Page End: 1086
• Publication Date: 2014-03-29
• Subjects: Geriatric psychiatry -- Periodicals; Geriatric Psychiatry -- Periodicals; 618.97689
• DOI: 10.1002/gps.4102
• Languages: English
• ISSNs: 0885-6230

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="gps4102-sec-0001" sec-type="section"> <title>Objectives</title> <p>The purpose of this study was to clarify the concordance of diagnostic abilities and interobserver agreement between <sup>18</sup>F‐fluorodeoxyglucose (FDG) positron emission tomography (PET) and brain perfusion single photon‐emission computed tomography (SPECT) in patients with Alzheimer's disease (AD) who were diagnosed according to the research criteria of the National Institute of Aging‐Alzheimer's Association Workshop.</p> </sec> <sec id="gps4102-sec-0002" sec-type="section"> <title>Methods</title> <p>Fifty‐five patients with "AD and mild cognitive impairment (MCI)" (<italic>n</italic> = 40) and "non‐AD" (<italic>n</italic> = 15) were evaluated with <sup>18</sup>F‐FDG PET and <sup>99m</sup>Tc‐ethyl cysteinate dimer (ECD) SPECT during an 8‐week period. Three radiologists independently graded the regional uptake in the frontal, temporal, parietal, and occipital lobes as well as the precuneus/posterior cingulate cortex in both images. Kappa values were used to determine the interobserver reliability regarding regional uptake.</p> </sec> <sec id="gps4102-sec-0003" sec-type="section"> <title>Results</title> <p>The regions with better interobserver reliability between <sup>18</sup>F‐FDG PET and <sup>99m</sup>Tc‐ECD SPECT were the frontal, parietal, and temporal lobes. The <sup>99m</sup>Tc‐ECD SPECT agreement in the occipital lobes was not significant. The frontal, temporal, and parietal lobes showed good correlations between <sup>18</sup>F‐FDG PET and <sup>99m</sup>Tc‐ECD SPECT in the degree of uptake, but the occipital lobe and precuneus/posterior cingulate cortex did not show good correlations. The diagnostic accuracy rates of "AD and MCI" ranged from 60% to 70% in both of the techniques.</p> </sec> <sec id="gps4102-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The degree of uptake on <sup>18</sup>F‐FDG PET and <sup>99m</sup>Tc‐ECD SPECT showed significant correlations in the frontal, temporal, and parietal lobes. The diagnostic abilities of <sup>18</sup>F‐FDG PET and <sup>99m</sup>Tc‐ECD SPECT for "AD and MCI, " when diagnosed according to the National Institute of Aging‐Alzheimer's Association Workshop criteria, were nearly identical. Copyright © 2014 John Wiley & Sons, Ltd.</p> </sec> </abstract>