Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling. (25th August 2014)

• Record Type: Journal Article
• Authors: Sun, Yue; Miller, Charles A.; Wiese, Thomas E.; Blake, Diane A.
• Is Part Of: Environmental toxicology and chemistry. Volume 33:Number 10(2014:Oct.)
• Page Start: 2363
• Page End: 2367
• Publication Date: 2014-08-25
• Subjects: Pollution -- Environmental aspects -- Periodicals; Environmental chemistry -- Periodicals; 615.902
• DOI: 10.1002/etc.2687
• Languages: English
• ISSNs: 0730-7268

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="etc2687-sec-0001" sec-type="section"> <p>Alkylated polycyclic aromatic hydrocarbons (APAHs) are abundant in petroleum, but data regarding their toxicological properties are limited. A survey of all monomethylated phenanthrene structures revealed that they were 2 times to 5 times more potent than phenanthrene for activation of human aryl hydrocarbon receptor in a yeast bioassay. Phenanthrenes with equatorial methyl groups had the greatest potency. The greater potency of the methylated phenanthrenes highlights the need for more toxicological data on APAHs. <italic>Environ Toxicol Chem</italic> 2014;33:2363–2367. © 2014 The Authors. <italic>Environmental Toxicology and Chemistry</italic> published by Wiley Periodicals, Inc. on behalf of SETAC.</p> </sec> </abstract>