The vertebrate corneal epithelium: From early specification to constant renewal. Issue 10 (30th August 2014)

• Record Type: Journal Article
• Authors: Dhouailly, Danielle; Pearton, David J.; Michon, Frederic; Mansour, Suzanne L.; Ornitz, David M.
• Is Part Of: Developmental dynamics. Volume 243:Issue 10(2014:Oct.)
• Page Start: 1226
• Page End: 1241
• Publication Date: 2014-08-30
• Subjects: Morphogenesis -- Periodicals; Anatomy -- Periodicals; Anatomie -- Périodiques; Biologie du développement -- Périodiques; 571.833
• DOI: 10.1002/dvdy.24179
• Languages: English
• ISSNs: 1058-8388

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <underline>BACKGROUND:</underline> The cornea is an ectodermal/neural crest derivative formed through a cascade of molecular mechanisms to give rise to the specific optical features necessary for its refractory function. Moreover, during cornea formation and maturation, epithelial stem cells are sequestered to ensure a constant source for renewal in the adult. <underline>RESULTS:</underline> Recent progress in the molecular and stem cell biology of corneal morphogenesis and renewal shows that it can serves as a paradigm for epithelial /mesenchymal organ biology. This review will synthesize historical knowledge together with recent data to present a consistent overview of cornea specification, formation, maturation, and maintenance. <underline>CONCLUSIONS:</underline> This should be of interest not only to developmental biologists but also ophthalmologists, as several human vision problems are known to be rooted in defects in corneal development. <italic>Developmental Dynamics 243:1226–1241, 2014</italic>. © 2014 Wiley Periodicals, Inc.</p> </abstract>