Genetic and intermediate phenotypic susceptibility markers of gastric cancer in Hispanic Americans: A case‐control study. Issue 19 (24th June 2014)

• Record Type: Journal Article
• Authors: Sun, Yuhui; Gu, Jian; Ajani, Jaffer A.; Chang, David W.; Wu, Xifeng; Stroehlein, John R.
• Is Part Of: Cancer. Volume 120:Issue 19(2014)
• Page Start: 3040
• Page End: 3048
• Publication Date: 2014-06-24
• Subjects: Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.28792
• Languages: English
• ISSNs: 0008-543X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="cncr28792-sec-0001" sec-type="section"> <title>BACKGROUND</title> <p>Hispanics are the largest nonwhite ethnic group in the US population, and they have higher incidence and mortality rates for gastric cancer (GC) than whites and Asians. Studies have identified several genetic susceptibility loci and intermediate phenotypic biomarkers for GC in whites and Asians. No studies have evaluated genetic susceptibility and intermediate phenotypic biomarkers in Hispanics.</p> </sec> <sec id="cncr28792-sec-0002" sec-type="section"> <title>METHODS</title> <p>In a case‐control study of 132 Hispanic patients with GC (cases) and a control group of 125 Hispanics (controls), the authors evaluated the association of 5 single nucleotide polymorphisms (SNPs) that predispose whites and/or Asians to GC and of 2 intermediate phenotypic markers in peripheral blood leukocytes, ie, telomere length and mitochondrial DNA (mtDNA) copy number, with the GC risk.</p> </sec> <sec id="cncr28792-sec-0003" sec-type="section"> <title>RESULTS</title> <p>The variant C allele of the reference SNP rs2294008 in the <italic>PSCA</italic> gene was associated with a significantly reduced risk of GC (per allele‐adjusted odds ratio [aOR], 0.51; 95% confidence interval [CI], 0.33‐0.77; <italic>P</italic> = .002). Leukocyte mtDNA copy numbers were significantly lower in GC cases (mean ± standard deviation, 0.91 ± 0.28) than in controls (1.29 ± 0.42; <italic>P</italic> < .001). When individuals were dichotomized into high and low mtDNA copy number groups based on the median mtDNA copy number value in the controls, those who had a low mtDNA copy number had a significantly increased risk of GC (aOR, 11.00; 95% CI, 4.79‐25.23; <italic>P</italic> < .001) compared with those who had a high mtDNA copy number. Telomere length was not associated significantly with the risk of GC (aOR, 1.21; 95% CI, 0.65‐2.27; <italic>P</italic> = .551).</p> </sec> <sec id="cncr28792-sec-0004" sec-type="section"> <title>CONCLUSIONS</title> <p>Hispanics share certain genetic susceptibility loci and intermediate phenotypic GC biomarkers with whites and Asians and may also have distinct genetic susceptibility factors. <bold><italic>Cancer</italic> 2014;120:3040–3048</bold>. © <italic>2014 American Cancer Society</italic>.</p> </sec> </abstract>