Synthesis, Enzymatic Resolution, and Stereochemical Characterization of Isoparaconic Acid Derivatives: A Combined Experimental and Theoretical Investigation. Issue 10 (28th July 2014)

• Record Type: Journal Article
• Authors: Felluga, Fulvia; Forzato, Cristina; Mazzeo, Giuseppe; Nitti, Patrizia; Pitacco, Giuliana; Superchi, Stefano
• Is Part Of: Chirality. Volume 26:Issue 10(2014:Oct.)
• Page Start: 640
• Page End: 650
• Publication Date: 2014-07-28
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22355
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Enantiomerically enriched isoparaconic acid derivatives were obtained by kinetic <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">enzymatic resolution</named-content>. To explain the solvent dependence observed for their optical rotatory power a computational investigation of their chiroptical properties was performed. <italic>Chirality 26:640–650, 2014.</italic> © 2014 Wiley Periodicals, Inc.</p> </abstract>