<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A efficient procedure using a bifunctional squaramide catalyst is presented for the domino Mannich cyclization of isatin imines and 1, 3‐dicarbonyl compounds (II) and (IV) to produce 3‐amino‐2‐oxindoles in high yields and excellent stereoselectivities.</p> </abstract>