Enantiopure Isoindolinones through Viedma Ripening. Issue 42 (28th August 2014)

• Record Type: Journal Article
• Authors: Steendam, René R. E.; Brouwer, Maxime C. T.; Huijs, Evelien M. E.; Kulka, Michaël W.; Meekes, Hugo; van Enckevort, Willem J. P.; Raap, Jan; Rutjes, Floris P. J. T.; Vlieg, Elias
• Is Part Of: Chemistry. Volume 20:Issue 42(2014)
• Page Start: 13527
• Page End: 13530
• Publication Date: 2014-08-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201404320
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Here we demonstrate that deracemization of isoindolinones using Viedma ripening is possible starting from a racemic mixture of conglomerate crystals. Crystals of the enantiopure isoindolinones lose their chiral identity upon dissolution even without the need for a catalyst. This enabled complete deracemization of the reported isoindolinones without a catalyst.</p> </abstract>