Proof of Concept of the Electrochemical Sensing of 3‐Iodothyronamine (T1AM) and Thyronamine (T0AM). Issue 10 (25th August 2014)

• Record Type: Journal Article
• Authors: Gonçalves, Luís M.; Moreira, Manuela M.; Azevedo, Carla F.; Valente, Inês M.; Sousa, João C.; Scanlan, Thomas S.; Compton, Richard G.; Rodrigues, José A.
• Is Part Of: ChemElectroChem. Volume 1:Issue 10(2014)
• Page Start: 1623
• Page End: 1626
• Publication Date: 2014-08-25
• Subjects: Electrochemistry -- Periodicals; 541.37
• DOI: 10.1002/celc.201402165
• Languages: English
• ISSNs: 2196-0216

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Recent studies have shown that, besides the well‐recognized T₃ and T₄ hormones, there are other relevant thyroid hormones circulating in the human body. In particular, this is the case for 3‐iodothyronamine (T₁AM) and thyronamine (T₀AM). One of the reasons for the lack of studies showing their precise importance is the absence of analytical methodologies available. Herein, for the first time, T₁AM and T₀AM are electrochemically characterized. T₀AM was sensed by means of a glassy carbon electrode; furthermore, T₁AM was sensed both with a graphitic surface (oxidatively) as well as with mercury (reductively). For both compounds, after oxidation, it was possible to observe the reversible redox reaction concerning the benzoquinone/hydroquinone couple, thus increasing the specificity of the electroanalysis. Therefore, this work provides the basis for an 'at‐point‐of‐use' electrochemical strip test for T₁AM and T₀AM.</p> </abstract>