Role of autophagy and mTOR signaling in neural differentiation of bone marrow mesenchymal stem cells. (18th August 2014)

• Record Type: Journal Article
• Authors: Li, Yanfei; Wang, Cuiqin; Zhang, Guangyu; Wang, Xiaohan; Duan, Ranran; Gao, Huili; Peng, Tao; Teng, Junfang; Jia, Yanjie
• Is Part Of: Cell biology international. Volume 38:Number 11(2014)
• Page Start: 1337
• Page End: 1343
• Publication Date: 2014-08-18
• Subjects: Cytology -- Periodicals; Cells -- Periodicals; 571.605
• DOI: 10.1002/cbin.10320
• Languages: English
• ISSNs: 1065-6995

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="cbin10320-sec-0001" sec-type="section"> <p>Autophagy is involved in cell differentiation. We present evidence that autophagy is activated during β‐mercaptoethanol (β‐ME)‐induced neuronal differentiation of bone marrow mesenchymal stem cells (MSCs), in which <italic>mammalian target of rapamycin</italic> (mTOR) signaling is important. mTOR activity declined after being transported from the nucleus to the cytoplasm. Using 3‐methyladenine (3‐MA) and rapamycin to regulate the activity of mTOR, it was found that the efficiency of neuronal differentiation was affected.</p> </sec> </abstract>