Coating of electrospun poly(lactic‐co‐glycolic acid) nanofibers with willemite bioceramic: improvement of bone reconstruction in rat model. (6th June 2014)

• Record Type: Journal Article
• Authors: Jamshidi Adegani, Fatemeh; Langroudi, Lida; Ardeshirylajimi, Abdolreza; Dinarvand, Peyman; Dodel, Masumeh; Doostmohammadi, Ali; Rahimian, Ali; Zohrabi, Parastoo; Seyedjafari, Ehsan; Soleimani, Masoud
• Is Part Of: Cell biology international. Volume 38:Number 11(2014)
• Page Start: 1271
• Page End: 1279
• Publication Date: 2014-06-06
• Subjects: Cytology -- Periodicals; Cells -- Periodicals; 571.605
• DOI: 10.1002/cbin.10318
• Languages: English
• ISSNs: 1065-6995

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="cbin10318-sec-0001" sec-type="section"> <p>We have investigated the combination effects of bioceramics and poly(lactide‐co‐glycolide) (PLGA) on bone reconstruction in calvarial critical size defects using a rat model. Willemite (Zn₂SiO₄) ceramics were prepared and coated on the surface of electrospun fabricated scaffolds. After scaffolds and nanoparticles characterization, osteoconductivity of the construct was analyzed using digital mammography, multislice spiral‐computed tomography (MSCT) imaging, and histological analysis. Eight weeks after implantation, no sign of inflammation was observed at the site of the osseous defect. The results showed that the ceramics supported bone regeneration and highest bone reconstruction were observed in willemite‐coated PLGA. This suggests that electrospun PLGA nanofibers coated with BG are potential candidate implants for bone tissue engineering applications.</p> </sec> </abstract>