Supramolecular Phosphatases Formed by the Self‐Assembly of the Bis(Zn2+–Cyclen) Complex, Copper(II), and Barbital Derivatives in Water1. Issue 10 (30th July 2014)

• Record Type: Journal Article
• Authors: Zulkefeli, Mohd; Hisamatsu, Yosuke; Suzuki, Asami; Miyazawa, Yuya; Shiro, Motoo; Aoki, Shin
• Is Part Of: Chemistry, an Asian journal. Volume 9:Issue 10(2014:Oct.)
• Page Start: 2831
• Page End: 2841
• Publication Date: 2014-07-30
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201402513
• Languages: English
• ISSNs: 1861-4728

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>In our previous paper, we reported that a dimeric Zn²⁺ complex with a 2, 2′‐bipyridyl linker (Zn₂L¹), cyanuric acid (CA), and a Cu²⁺ ion automatically assemble in aqueous solution to form 4:4:4 complex <bold>3</bold>, which selectively catalyzes the hydrolysis of mono(4‐nitrophenyl)phosphate (MNP) at neutral pH. Herein, we report that the use of barbital (Bar) instead of CA for the self‐assembly with Zn₂L¹ and Cu²⁺ induces 2:2:2 complexation of these components, and not the 4:4:4 complex, to form supramolecular complex <bold>6 a</bold>, the structure and equilibrium characteristics of which were studied by analytical and physical measurements. The finding show that <bold>6 a</bold> also accelerates the hydrolysis of MNP, similarly to <bold>3</bold>. Moreover, inspired by the crystal structure of <bold>6 a</bold>, we prepared barbital units that contain functional groups on their side chains in an attempt to produce supramolecular phosphatases that possess functional groups near the Cu₂(μ‐OH)₂ catalytic core so as to mimic the catalytic center of alkaline phosphatase (AP).</p> </abstract>