In situ formation of biodegradable dextran‐based hydrogel via Michael addition. Issue 1 (27th April 2012)

• Record Type: Journal Article
• Authors: Peng, Geng; Wang, Jing; Yang, Fan; Zhang, Shuo; Hou, Juan; Xing, Wanli; Lu, Xun; Liu, Changsheng
• Is Part Of: Journal of applied polymer science. Volume 127:Issue 1(2013:Jan. 05)
• Page Start: 577
• Page End: 584
• Publication Date: 2012-04-27
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.37825
• Languages: English
• ISSNs: 0021-8995

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Vinyl‐sulfone‐functionalized dextran (Dex‐VS) was readily prepared by a single‐batch synthetic procedure at room temperature. The thiol molecule, 1, 4‐dithioerythritol (DTE, commercially available) with two terminal thiol groups was used as crosslinking agent. Hydrogels were rapidly prepared <italic>in situ</italic> by Michael addition under mild physiological conditions. Properties including gelation duration, mechanical modulus, and degradation behavior could be expediently controlled. Moreover, the hydrogels had comparatively low cytotoxicity, and the <italic>in vivo</italic> tests demonstrated an effective delivery of growth factor. This study might provide a powerful material to be used in tissue regeneration. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2012</p> </abstract>