ANGIOGENIC IMBALANCES IN THE PATHOGENESIS OF PREGNANCY COMPLICATIONS. (17th September 2014)

• Record Type: Journal Article
• Authors: ESPINOZA, JIMMY
• Is Part Of: Fetal and maternal medicine review. Volume 25:Number 1(2014:Feb.)
• Page Start: 42
• Page End: 58
• Publication Date: 2014-09-17
• Subjects: Fetus -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Obstetrics -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3
• DOI: 10.1017/S0965539514000096
• Languages: English
• ISSNs: 0965-5395

Abstract

<abstract abstract-type="text-abstract"> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <p>Endothelial cell proliferation and survival require continuous low levels of vascular endothelial growth factor (VEGF). The bioavailability of this angiogenic factor appears to be regulated by anti-angiogenic factors, including the soluble form of VEGF receptor 1 (sFlt-1) in the non-pregnant and pregnant states. During pregnancy a VEGF antagonist (sFlt-1) and other anti-angiogenic factors, including soluble endoglin (s-Eng), are produced by the human placenta and released into the maternal circulation; an excess of these anti-angiogenic factors can lead into angiogenic imbalances and pregnancy complications. This is important because regulation of VEGF action on angiogenic balances appears to be essential for a successful pregnancy.</p> </abstract>