An Organocatalytic Azide–Aldehyde [3+2] Cycloaddition: High‐Yielding Regioselective Synthesis of 1, 4‐Disubstituted 1, 2, 3‐Triazoles1. Issue 39 (30th July 2014)

• Record Type: Journal Article
• Authors: Ramachary, Dhevalapally B.; Shashank, Adluri B.; Karthik, S.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 39(2014)
• Page Start: 10420
• Page End: 10424
• Publication Date: 2014-07-30
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201406721
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An organocatalytic azide–aldehyde [3+2] cycloaddition (organo‐click) reaction of a variety of enolizable aldehydes is reported. The organo‐click reaction is characterized by a high rate and regioselectivity, mild reaction conditions, easily available substrates with simple operation, and excellent yields with a broad spectrum of substrates. It constitutes an alternative to the previously known CuAAC, RuAAC, and IrAAC click reactions.</p> </abstract>