Multigenerational effects of whole body exposure to 2.14 GHz W‐CDMA cellular phone signals on brain function in rats. Issue 7 (4th September 2014)

• Record Type: Journal Article
• Authors: Shirai, Tomoyuki; Imai, Norio; Wang, Jianqing; Takahashi, Satoru; Kawabe, Mayumi; Wake, Kanako; Kawai, Hiroki; Watanabe, So‐Ichi; Furukawa, Fumio; Fujiwara, Osamu
• Is Part Of: Bioelectromagnetics. Volume 35:Issue 7(2014:Oct.)
• Page Start: 497
• Page End: 511
• Publication Date: 2014-09-04
• Subjects: Electromagnetism -- Physiological effect -- Periodicals; 571.47
• DOI: 10.1002/bem.21871
• Languages: English
• ISSNs: 0197-8462

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bem21871-sec-0001" sec-type="section"> <p>The present experimental study was carried out with rats to evaluate the effects of whole body exposure to 2.14 GHz band code division multiple access (W‐CDMA) signals for 20 h a day, over three generations. The average specific absorption rate (SAR, in unit of W/kg) for dams was designed at three levels: high (<0.24 W/kg), low (<0.08 W/kg), and 0 (sham exposure). Pregnant mothers (4 rats/group) were exposed from gestational day (GD) 7 to weaning and then their offspring (F<sub>1</sub> generation, 4 males and 4 females/dam, respectively) were continuously exposed until 6 weeks of age. The F<sub>1</sub> females were mated with F<sub>1</sub> males at 11 weeks old, and then starting from GD 7, they were exposed continuously to the electromagnetic field (EMF; one half of the F1 offspring was used for mating, that is, two of each sex per dam and 8 males and 8 females/group, except for all offspring for the functional development tests). This protocol was repeated in the same manner on pregnant F<sub>2</sub> females and F<sub>3</sub> pups; the latter were killed at 10 weeks of age. No abnormalities were observed in the mother rats (F<sub>0</sub>, F<sub>1</sub>, and F<sub>2</sub>) and in the offspring (F<sub>1</sub>, F<sub>2</sub>, and F<sub>3</sub>) in any biological parameters, including neurobehavioral function. Thus, it was concluded that under the experimental conditions applied, multigenerational whole body exposure to 2.14 GHz W‐CDMA signals for 20 h/day did not cause any adverse effects on the F<sub>1</sub>, F<sub>2</sub>, and F<sub>3</sub> offspring. Bioelectromagnetics. 35:497–511, 2014. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>