Hydrogen Bond Mediated Aglycone Delivery: Synthesis of Linear and Branched α‐Glucans1. (12th August 2014)

• Record Type: Journal Article
• Authors: Yasomanee, Jagodige P.; Demchenko, Alexei V.
• Is Part Of: Angewandte Chemie. Volume 126:Number 39(2014)
• Page Start: 10621
• Page End: 10624
• Publication Date: 2014-08-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201405084
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A Hydrogen bond mediated aglycone delivery (HAD) method was applied to the synthesis of α‐glucans, which are abundant in nature, but as targets represent a notable challenge to chemists. The synthesis of linear oligosaccharide sequences was accomplished in complete stereoselectivity in all glycosylations. The efficacy of HAD may diminish with the increased bulk of the glycosyl acceptor, and may be an important factor for the syntheses of oligomers beyond pentasaccharides. The synthesis of a branched structure proved more challenging, particularly with bulky trisaccharide acceptors.</p> </abstract>