Recent advances on cellular therapies and immune modulators for graft-versus-host disease. (October 2014)

• Record Type: Journal Article
• Authors: Filippini, Perla; Rutella, Sergio
• Is Part Of: Expert review of clinical immunology. Volume 10:Number 10(2014)
• Page Start: 1357
• Page End: 1374
• Publication Date: 2014-10
• Subjects: Clinical immunology -- Periodicals; 616.079
• DOI: 10.1586/1744666X.2014.955475
• Languages: English
• ISSNs: 1744-666X

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>The efficacy of allogeneic hematopoietic stem cell transplantation is counterbalanced by the occurrence of life-threatening immune-mediated complications, such as graft-versus-host disease (GVHD), a multistep disease which is reportedly fatal to approximately 15% of transplant recipients. It is now established that T-cell–dendritic cell interactions, T-cell activation, release of proinflammatory cytokines and T-cell trafficking partake in GVHD pathogenesis. This article will focus on the most recent strategies aimed at preventing/treating GVHD by manipulating components of the innate and adaptive immune response from both the donor and the host.</p> </abstract>