Polymorphisms of genes encoding P2X7R, IL‐1B, OPG and RANK in orthodontic‐induced apical root resorption. (31st October 2013)

• Record Type: Journal Article
• Authors: Pereira, S; Lavado, N; Nogueira, L; Lopez, M; Abreu, J; Silva, H
• Is Part Of: Oral diseases. Volume 20:Number 7(2014:Oct.)
• Page Start: 659
• Page End: 667
• Publication Date: 2013-10-31
• Subjects: Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12185
• Languages: English
• ISSNs: 1354-523X

Abstract

<abstract abstract-type="main" id="odi12185-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="odi12185-sec-0001" sec-type="section"> <title>Objective</title> <p>Orthodontic‐induced external apical root resorption (EARR) is a complex phenotype determined by poorly defined mechanical and patient intrinsic factors. The aim of this work was to construct a multifactorial integrative model, including clinical and genetic susceptibility factors, to analyze the risk of developing this common orthodontic complication.</p> </sec> <sec id="odi12185-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>This retrospective study included 195 orthodontic patients. Using a multiple‐linear regression model, where the dependent variable was the maximum% of root resorption (%EARRmax) for each patient, we assessed the contribution of nine clinical variables and four polymorphisms of genes involved in bone and tooth root remodeling (rs1718119 from <italic>P2RX7</italic>, rs1143634 from <italic>IL1B</italic>, rs3102735 from <italic>TNFRSF11B</italic>, encoding OPG, and rs1805034 from <italic>TNFRSF11A</italic>, encoding RANK).</p> </sec> <sec id="odi12185-sec-0003" sec-type="section"> <title>Results</title> <p>Clinical and genetic variables explained 30% of%EARRmax variability. The variables with the most significant unique contribution to the model were: gender (<italic>P </italic><<italic> </italic>0.05), treatment duration (<italic>P </italic><<italic> </italic>0.001), premolar extractions (<italic>P </italic><<italic> </italic>0.01), Hyrax appliance (<italic>P </italic><<italic> </italic>0.001) and GG genotype of rs1718119 from <italic>P2RX7</italic> gene (<italic>P </italic><<italic> </italic>0.01). Age, overjet, tongue thrust, skeletal class II and the other polymorphisms made minor contributions.</p> </sec> <sec id="odi12185-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This study highlights the <italic>P2RX7</italic> gene as a possible factor of susceptibility to EARR. A more extensive genetic profile may improve this model.</p> </sec> </abstract>