Peripheral Antinociception and Anti‐Inflammatory Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana. (18th April 2014)

• Record Type: Journal Article
• Authors: Carneiro, José Gerardo; Rodrigues, José Ariévilo Gurgel; de Sousa Oliveira Vanderlei, Edfranck; Souza, Ricardo Basto; Quinderé, Ana Luíza Gomes; Coura, Chistiane Oliveira; de Araújo, Ianna Wivianne Fernandes; Chaves, Hellíada Vasconcelos; Bezerra, Mirna Marques; Benevides, Norma Maria Barros
• Is Part Of: Basic & clinical pharmacology & toxicology. Volume 115:Number 4(2014:Apr.)
• Page Start: 335
• Page End: 342
• Publication Date: 2014-04-18
• Subjects: Pharmacology -- Periodicals; Toxicology -- Periodicals; Pharmacology -- Periodicals; Toxicology -- Periodicals; Pharmacology, Clinical -- Periodicals; Computer network resources; Electronic journals; 615.1
• DOI: 10.1111/bcpt.12234
• Languages: English
• ISSNs: 1742-7835

Abstract

<abstract abstract-type="main" id="bcpt12234-abs-0001"> <title>Abstract</title> <p>Sulphated polysaccharides from marine algae are widely used in biotechnological and pharmaceutical areas. In this study, we evaluated the effects of sulphated polysaccharides from the green marine alga <italic>Caulerpa mexicana</italic> (Cm‐SPs) in nociceptive and inflammatory models in rodents. Cm‐SPs (10 or 20 mg/kg), administered i.v. in <italic>Swiss</italic> mice, significantly reduced nociceptive responses, as measured by the number of writhes in response to acetic acid. Cm‐SPs (10 or 20 mg/kg) also reduced second‐phase responses in the formalin test, but did not exhibit a significant antinociceptive effect in the hot plate test, suggesting that its antinociceptive action occurs through a peripheral mechanism. Cm‐SPs (5, 10 or 20 mg/kg), administered s.c. in <italic>wistar</italic> rats 1 hr before carrageenan, dextran, histamine or serotonin, were tested in paw oedema models. Cm‐SPs (10 or 20 mg/kg) reduced carrageenan‐induced paw oedema and myeloperoxidase activity in the paw. In addition, Cm‐SPs (20 mg/kg) inhibited dextran‐ or histamine‐induced paw oedema, but not serotonin‐induced oedema, suggesting that histamine is the major target of Cm‐SPs anti‐oedematogenic activity. Finally, Cm‐SPs (20 mg/kg) administered in mice did not show significant signs of toxicity. In conclusion, Cm‐SPs appear to be promising natural modulatory agents for pain and inflammatory conditions.</p> </abstract>