Amide proton transfer imaging of high intensity focused ultrasound‐treated tumor tissue. Issue 4 (23rd October 2013)

• Record Type: Journal Article
• Authors: Hectors, Stefanie J.C.G.; Jacobs, Igor; Strijkers, Gustav J.; Nicolay, Klaas
• Is Part Of: Magnetic resonance in medicine. Volume 72:Issue 4(2014:Oct.)
• Page Start: 1113
• Page End: 1122
• Publication Date: 2013-10-23
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25000
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm25000-sec-0001" sec-type="section"> <title>Purpose</title> <p>In this study, the suitability of amide proton transfer (APT) imaging as a biomarker for the characterization of high intensity focused ultrasound (HIFU)‐treated tumor tissue was assessed.</p> </sec> <sec id="mrm25000-sec-0002" sec-type="section"> <title>Methods</title> <p>APT imaging was performed on tumor‐bearing mice before (n = 15), directly after (n = 15) and at 3 days (n = 8) after HIFU treatment. A control group (n = 7) of nontreated animals was scanned at the same time points. Histogram analysis of the tumor APT‐weighted signal distributions was performed to assess HIFU‐induced changes in the tumor APT contrast.</p> </sec> <sec id="mrm25000-sec-0003" sec-type="section"> <title>Results</title> <p>Distinct regions of decreased APT‐weighted signal were observed at both time points after HIFU treatment. Analysis of the tumor APT‐weighted signal distribution showed a pronounced shift toward lower APT‐weighted signal values after HIFU treatment. A significantly increased fraction of pixels with an APT‐weighted signal value between −10 and −2% was observed both directly (0.37 ± 0.16) and at 3 days (0.49 ± 0.16) after HIFU treatment as compared to baseline (0.22 ± 0.16).</p> </sec> <sec id="mrm25000-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The presented results show that APT imaging is sensitive to HIFU‐induced changes in tumor tissue and may thus serve as a new biomarker for monitoring the response of tumor tissue to HIFU treatment. <bold>Magn Reson Med 72:1113–1122, 2014. © 2013 Wiley Periodicals, Inc.</bold></p> </sec> </abstract>