Cover Picture: Computational Molecular Biophysics: 40 Years of Achievements (Isr. J. Chem. 8‐9/2014). Issue 8 (August 2014)

• Record Type: Journal Article
• Authors: Levy, Yaakov; Skolnick, Jeffrey
• Is Part Of: Israel journal of chemistry. Volume 54:Issue 8/9(2014)
• Page Start: 1027
• Page End: 1027
• Publication Date: 2014-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/ijch.201490015
• Languages: English
• ISSNs: 0021-2148

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>This special volume focuses on Computational molecular biophysics in honor of the 2013 Nobel Prize in Chemistry awarded to Karplus (right), Levitt (middle), and Warshel (left). In a series of seminal contributions, the three laureates provided novel approaches to study complex chemical systems. The cover shows the fundamental energy terms used in many transferrable force‐fields to calculate the structure of a variety of biomolecules. Force‐fields are still widely used, both in atomistic or coarse‐grained forms, to decipher the conformational landscape (represented by the white curve) of proteins and their folding mechanism. The cover also illustrates the achievement of the Nobel laureates to study the action of an enzyme (the cover highlights Lysozyme that breaks polysaccharides into smaller fragments) by carefully integrating quantum and classical calculations. See the Guest Editorial on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 1039</ext-link>.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh1c5j5t7r" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>