Quantitative evaluation of liver function with T1 relaxation time index on Gd‐EOB‐DTPA‐enhanced MRI: Comparison with signal intensity‐based indices. Issue 4 (5th November 2013)

• Record Type: Journal Article
• Authors: Kamimura, Kiyohisa; Fukukura, Yoshihiko; Yoneyama, Tomohide; Takumi, Koji; Tateyama, Akihiro; Umanodan, Aya; Shindo, Toshikazu; Kumagae, Yuichi; Ueno, Shin‐ichi; Koriyama, Chihaya; Nakajo, Masayuki
• Is Part Of: Journal of magnetic resonance imaging. Volume 40:Issue 4(2014)
• Page Start: 884
• Page End: 889
• Publication Date: 2013-11-05
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24443
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24443-sec-0001" sec-type="section"> <title>Purpose</title> <p>To evaluate whether the reduction rate of T1 relaxation time of the liver (T1 relaxation time index) before and 20 minutes after gadolinium‐ethoxybenzyl‐diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA) injection has the potential to serve as an magnetic resonance imaging (MRI)‐based liver function test in comparison with signal intensity‐based indices.</p> </sec> <sec id="jmri24443-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Ninety‐nine patients with suspected liver lesions underwent Gd‐EOB‐DTPA‐enhanced MRI. T1 maps using 3D T1‐weighted gradient‐echo volumetric interpolated examination with two different flip angles were also performed before and 20 minutes after Gd‐EOB‐DTPA administration. T1 relaxation time index was compared with four signal intensity‐based indices in terms of the ability to discriminate Child‐Pugh A (CPA) and Child‐Pugh B (CPB) from normal liver function (NLF), and in terms of its correlation with indocyanine green (ICG) clearance.</p> </sec> <sec id="jmri24443-sec-0003" sec-type="section"> <title>Results</title> <p>Twenty‐four patients were classified as NLF, 64 patients were classified as CPA, and 11 were classified as CPB group. The T1 relaxation time index was significantly lower for CPA (0.62 ± 0.08 vs. 0.68 ± 0.07, <italic>P</italic> = 0.021) and CPB (0.55 ± 0.15 vs. 0.68 ± 0.07, <italic>P</italic> < 0.001) than for NLF. All signal intensity‐based indices showed significant differences only when comparing NLF and CPB. The correlation coefficient with ICG clearance was the highest for T1 relaxation time index (<italic>r</italic> = −0.605, <italic>P</italic> < 0.001).</p> </sec> <sec id="jmri24443-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The T1 relaxation time index has the potential to serve as an MRI‐based liver function test, and is most strongly correlated with ICG clearance among the Gd‐EOB‐DTPA MRI‐based indices investigated. <bold>J. Magn. Reson. Imaging 2014;40:884–889</bold>. © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>