Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease. (August 2014)

• Record Type: Journal Article
• Authors: Nakamura, Miho; Nakamura, Hidetoshi; Minematsu, Naoto; Chubachi, Shotaro; Miyazaki, Masaki; Yoshida, Shuichi; Tsuduki, Keishi; Shirahata, Toru; Mashimo, Shuko; Takahashi, Saeko; Nakajima, Takahiro; Tateno, Hiroki; Fujishima, Seitaro; Betsuyaku, Tomoko
• Is Part Of: Biomarkers. Volume 19:Number 5(2014)
• Page Start: 368
• Page End: 377
• Publication Date: 2014-08
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2014.915342
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p>Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV₁) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as <italic>Non-smokers</italic> using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.</p> </abstract>