Subcutaneous hyalohyphomycosis caused by Fusarium in a kidney transplant recipient. (August 2014)

• Record Type: Journal Article
• Authors: Keskar, Vaibhav S.; Wanjare, Shashir; Jamale, Tukaram E.; Mahajan, Dinesh; Jawale, Sunil Y.; Fernandes, Gwendolyn; Suryawanshi, Rupali; Hase, N. K.
• Is Part Of: Renal failure. Volume 36:Number 7(2014)
• Page Start: 1129
• Page End: 1132
• Publication Date: 2014-08
• Subjects: Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2014.926756
• Languages: English
• ISSNs: 0886-022X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Fusarium</italic> is a filamentous opportunistic pathogenic fungus responsible for superficial as well as invasive infection in immunocompromized hosts. Net state of immunosuppression and cytomegalovirus (CMV) infection appear to predispose to this disease which is life-threatening when disseminated. Though infections with <italic>Fusarium</italic> have been widely described in hematological malignancies and hematopoietic stem cell transplant cases, they have been reported to be rare in solid organ transplant recipients, are often localized and carry a favorable prognosis. We here describe a rare case of subcutaneous non-invasive infection with <italic>Fusarium</italic> in a renal allograft recipient two and half years after transplantation. Patient had a previous history of CMV infection along with multiple other recurrent co-infections. Diagnosis was based on culture of tissue specimens yielding <italic>Fusarium</italic> species. The infection had a protracted course with persistence of lesions after treatment with voriconazole alone, requiring a combination of complete surgical excision and therapy with the anti-fungal drug.</p> </abstract>