High-normal blood pressure, functional capacity and left heart mechanics: Is there any connection?. (October 2014)

• Record Type: Journal Article
• Authors: Tadic, Marijana; Cuspidi, Cesare; Backovic, Sladjana; Kleut, Milena; Ivanovic, Branislava; Scepanovic, Radisav; Iracek, Olinka; Celic, Vera
• Is Part Of: Blood pressure. Volume 23:Number 5(2014)
• Page Start: 315
• Page End: 321
• Publication Date: 2014-10
• Subjects: Blood pressure -- Periodicals; Hypertension -- Periodicals; Hypertension -- Periodicals; Blood Pressure -- Periodicals; 612.14
• DOI: 10.3109/08037051.2014.907978
• Languages: English
• ISSNs: 0803-7051

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective.</italic> To evaluate the relationship between functional capacity and left ventricular (LV) and left atrial (LA) myocardial deformation, assessed by two- and three-dimensional (2DE and 3DE) strain analysis, in subjects with high-normal blood pressure (BP). <italic>Methods.</italic> This cross-sectional study included 64 subjects with optimal BP and 75 subjects with high-normal BP of similar gender and age. All the subjects underwent a complete 2DE and 3DE examination and cardiopulmonary exercise testing. <italic>Results.</italic> 3DE global longitudinal strain was significantly lower in the group with high-normal BP than in the optimal BP group (− 20.1 ± 2.4 vs − 18.5 ± 2.3%, <italic>p < </italic>0.001). Similar results were obtained for 3DE global circumferential strain (− 21.8 ± 2.6 vs − 19.3 ± 2.4%, <italic>p < </italic>0.001), as well as for 3DE global radial strain (45.1 ± 8.8 vs 42.3 ± 7.2%, <italic>p = </italic>0.042), and 3DE global area strain (− 30.1 ± 4.2 vs − 28.1 ± 3.8%, <italic>p < </italic>0.001). LV twist was similar between the observed groups, whereas untwisting rate was significantly decreased in the subjects with high-normal BP (− 123 ± 30 vs − 112 ± 26°/s, <italic>p = </italic>0.023). Peak VO2 was significantly lower in the high-normal BP group (30.8 ± 4 vs 28.3 ± 3.7 ml/kg/min, <italic>p < </italic>0.001). 2DE LV ejection fraction (β = 0.38, <italic>p = </italic>0.014), 2DE global longitudinal strain (β = 0.35, <italic>p = </italic>0.019) and 3DE global longitudinal strain (β = 0.27, <italic>p = </italic>0.042) were independently associated with peak VO2. <italic>Conclusion</italic>. LV and LA mechanics, as well as functional capacity are significantly impaired in the subjects with high-normal BP. LV and LA myocardial deformations are associated with peak oxygen uptake.</p> </abstract>