A randomized controlled trial: the efficacy of eluoride rinse combined with calcium pre-rinse to increase overnight salivary fluoride. (October 2013)

• Record Type: Journal Article
• Authors: Chen, Margaret Sällberg; Strömberg, Elin; Vogel, Gerald Lee; Sandborgh-Englund, Gunilla
• Is Part Of: Acta odontologica Scandinavica. Volume 72:Number 7(2014)
• Page Start: 557
• Page End: 560
• Publication Date: 2013-10
• Subjects: Dentistry -- Periodicals; 617.6005
• DOI: 10.3109/00016357.2013.859729
• Languages: English
• ISSNs: 0001-6357

Abstract

<abstract> <title>Abstract</title> <p> <bold> <italic>Background.</italic> </bold> Previous studies have shown that a calcium (Ca) pre-rinse given before a 228 ppm fluoride (F) rinse greatly increased salivary fluoride. <bold><italic>Objectives.</italic></bold> The aim of this randomized controlled trial is to examine if Ca pre-rinse could increase the fluoride concentration in the overnight unstimulated saliva after a 905 ppm F-rinse. <bold><italic>Materials and methods.</italic></bold> Pre-rinses containing 150 mM, 75 mM or 0 mM Ca-lactate prepared by a validated pharmaceutical cGPM procedure were tested by nine subjects in a randomized order immediately followed by a 905 ppm F-rinse. The fluoride concentration was measured in unstimulated saliva collected 10 h later. <bold><italic>Results and conclusions.</italic></bold> The Ca pre-treatment significantly increased F level in overnight saliva following the 905 ppm fluoride rinse by 1.7× relative to the 905 ppm F-rinse alone; however, a significant effect was only observed with the highest (150 mM) Ca concentration as pre-rinse. <bold><italic>Clinical relevance.</italic></bold> High concentration F rinses (905 ppm) are commonly recommended for patients at high-risk of caries. A pre-treatment with high levels of Ca may further improve the cariostatic effect of this ion.</p> </abstract>