Long-term functional outcomes and quality of life after oncologic surgery and microvascular reconstruction in patients with oral or oropharyngeal cancer. (October 2014)

• Record Type: Journal Article
• Authors: Pierre, Cédric S.; Dassonville, Olivier; Chamorey, Emmanuel; Poissonnet, Gilles; Riss, Jean-Christophe; Ettaiche, Marc; Peyrade, Frédéric; Benezery, Karen; Chand, Marie-Eve; Leyssalle, Axel; Sudaka, Anne; Haudebourg, Juliette; Santini, José; Bozec, Alexandre
• Is Part Of: Acta oto-laryngologica. Volume 134:Number 10(2014)
• Page Start: 1086
• Page End: 1093
• Publication Date: 2014-10
• Subjects: Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.3109/00016489.2014.913809
• Languages: English
• ISSNs: 0001-6489

Abstract

<abstract> <title>Abstract</title> <p> <italic>Conclusions:</italic> Surgery for oral or oropharyngeal cancer with free-flap reconstruction is associated with moderate but persistent functional and quality of life (QoL) problems. Patient age, tumor stage, tumor site, and radiotherapy were the main predictors of functional outcome. <italic>Objectives:</italic> To evaluate long-term functional outcomes and QoL, and to determine their predictive factors in patients with oral or oropharyngeal cancer after oncologic surgery and free-flap reconstruction. <italic>Methods:</italic> Patients who underwent surgery with free-flap reconstruction for oral or oropharyngeal cancer between 2000 and 2009 who were alive at least 1 year after therapy were included in this study. Patients completed the Voice Handicap Index (VHI-10) questionnaire and the European Organization for Research and Treatment of Cancer (EORTC) QoL questionnaires QLQ-C30 and H&N35. Swallowing was evaluated using the Dysphagia Outcome and Severity Scale (DOSS) and by flexible fiberoptic laryngoscopy. <italic>Results:</italic> Sixty-four patients were included in the study. VHI-10 mean score was 11.2 ± 9 and its predictive factors were T stage (<italic>p</italic> = 0.005) and tumor involvement of the tongue base (<italic>p</italic> = 0.01). The mean DOSS score was 4 ± 0.8. Age (<italic>p</italic> = 0.008), gender (<italic>p</italic> = 0.04), and radiotherapy (<italic>p</italic> = 0.001) were the main predictive factors of the DOSS score.</p> </abstract>