A comparison between 15-day sequential, 10-day sequential and proton pump inhibitor-based triple therapy for Helicobacter pylori infection in Korea. (August 2014)

• Record Type: Journal Article
• Authors: Lee, Jung Won; Kim, Nayoung; Kim, Jung Mogg; Nam, Ryoung Hee; Kim, Jae Yeon; Lee, Ju Yup; Lee, Dong Ho; Jung, Hyun Chae
• Is Part Of: Scandinavian journal of gastroenterology. Volume 49:Number 8(2014)
• Page Start: 917
• Page End: 924
• Publication Date: 2014-08
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.3109/00365521.2014.896409
• Languages: English
• ISSNs: 0036-5521

Abstract

<abstract> <title>Abstract</title> <p> <bold> <italic>Objective.</italic> </bold> The eradication rate of 10-day sequential therapy for <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infection was not satisfactory in Korea, probably due to antibiotic resistance. To compare the treatment efficacy of 15-day and 10-day sequential therapy of conventional 7-day proton pump inhibitor (PPI) triple therapy for the treatment of <italic>H. pylori</italic> infection. <bold><italic>Methods.</italic></bold> A total of 332 patients with <italic>H. pylori</italic> infection were randomly assigned to receive either 7-day PPI triple therapy, 10-day sequential therapy or 15-day sequential therapy. Eradication rate, drug compliance, and adverse events were compared among the three regimens. <bold><italic>Results.</italic></bold> The eradication rates by intention-to-treat analysis were 64.3% (95% CI: 55.5–73.2; 74 of 115 patients), 72.1% (95% CI: 63.6–80.5; 80 of 111 patients), and 80.2% (95% CI: 72.5–87.9; 85 of 106 patients) in the 7-day PPI triple, 10-day and 15-day sequential therapy groups, respectively (<italic>p</italic> = 0.032). The eradication rates by per-protocol analysis were 68.5% (95% CI: 59.6–77.4; 74 of 108 patients), 78.4% (95% CI: 70.3–86.5; 80 of 102 patients), and 89.5% (95% CI: 83.2–95.8; 85 of 95 patients) in the 7-day PPI triple, 10-day and 15-day sequential therapy groups, respectively (<italic>p</italic> = 0.001). There were no statistically significant differences between the three eradication therapy groups in regard to drug compliance and adverse events. <bold><italic>Conclusion.</italic></bold> The 15-day sequential therapy demonstrated improved eradication efficacy compared with 7-day PPI triple and 10-day sequential therapy in Korea.</p> </abstract>