Probing the Dimerization Interface of Leishmania infantum Trypanothione Reductase with Site‐Directed Mutagenesis and Short Peptides. Issue 10 (6th June 2013)

• Record Type: Journal Article
• Authors: Toro, Miguel A.; Sánchez‐Murcia, Pedro A.; Moreno, David; Ruiz‐Santaquiteria, Marta; Alzate, Juan Fernando; Negri, Ana; Camarasa, María‐José; Gago, Federico; Velázquez, Sonsoles; Jiménez‐Ruiz, Antonio
• Is Part Of: Chembiochem. Volume 14:Issue 10(2013)
• Page Start: 1212
• Page End: 1217
• Publication Date: 2013-06-06
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201200744
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Binding at the interface:</bold> We tested the inhibitory activity of a set of peptide sequences derived from an α‐helix of the dimeric trypanothione reductase from <italic>Leishmania infantum.</italic> Replacement of a glutamic acid residue with a lysine promoted monomer dissociation and enzyme inhibition.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh190w2v5c" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>