Mapping algorithms from QLQ-C30 to EQ-5D utilities: no firm ground to stand on yet. (August 2014)

• Record Type: Journal Article
• Authors: Crott, Ralph
• Is Part Of: Expert review of pharmacoeconomics & outcomes research. Volume 14:Number 4(2014)
• Page Start: 569
• Page End: 576
• Publication Date: 2014-08
• Subjects: Pharmacology -- Economic aspects -- Periodicals; 338.47615105
• DOI: 10.1586/14737167.2014.908711
• Languages: English
• ISSNs: 1473-7167

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Aim: Over the last years several mapping or cross-walking algorithms for deriving utilities from QLQ-C30 scores have been published. However their external predictive accuracy has not yet been systematically compared. Methods: We tested the external validity of previously published mapping algorithms to transform the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire responses to EQ-5D derived Utilities. Results: When applied to different data sets, the currently published mapping showed a large variation between algorithms of the values of the mapped utilities, a low accuracy of the mapping compared to the observed EQ-5D utilities and no consistent performance between competing algorithms. Discussion: Therefore direct mapping from QLQ-C30 profiles to EQ-5D utilities using published algorithms should be viewed cautiously.</p> </abstract>