Depressive symptoms are associated with fasting insulin resistance in obese youth. Issue 5 (26th May 2014)

• Record Type: Journal Article
• Authors: Hannon, T. S.; Li, Z.; Tu, W.; Huber, J. N.; Carroll, A. E.; Lagges, A. M.; Gupta, S.
• Is Part Of: Pediatric obesity. Volume 9:Issue 5(2014:Oct.)
• Page Start: e103
• Page End: e107
• Publication Date: 2014-05-26
• Subjects: Obesity in children -- Periodicals; Obesity in adolescence -- Periodicals; Obesity -- Periodicals; Overweight children -- Periodicals; 618.92398
• DOI: 10.1111/ijpo.237
• Languages: English
• ISSNs: 1747-7174

Abstract

<abstract abstract-type="main"> <title>Summary</title> <sec id="ijpo237-sec-0001" sec-type="section"> <title>Background</title> <p>In adults, depressive symptoms are positively associated with insulin resistance.</p> </sec> <sec id="ijpo237-sec-0002" sec-type="section"> <title>Objective</title> <p>To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth.</p> </sec> <sec id="ijpo237-sec-0003" sec-type="section"> <title>Methods</title> <p>This study used a retrospective review of data from an obesity clinic. We evaluated the association between depressive symptoms (Children's Depression Inventory, CDI) and fasting insulin and homeostatic model assessment‐insulin resistance (HOMA‐IR) in obese youth (<italic>n</italic> = 207, age 10–18 years). Individuals with lower vs. higher CDI T‐scores (<65 vs. ≥65) were compared; this cut‐point is accepted as indicating the possibility of clinical depression. Multiple linear regression was used to evaluate relationships between CDI T‐scores and insulin resistance.</p> </sec> <sec id="ijpo237-sec-0004" sec-type="section"> <title>Results</title> <p>Fasting insulin and HOMA‐IR values were 40% higher in patients with higher CDI T‐scores (<italic>P</italic> = 0.04). After accounting for gender, race, age and body mass index, CDI T‐score remained associated with HOMA‐IR, although the strength of the association was small (b = 0.007, <italic>P</italic> = 0.049).</p> </sec> <sec id="ijpo237-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Relationships between depressive symptoms and insulin resistance should be considered when evaluating obese youth.</p> </sec> </abstract>