Safety of early endarterectomy in patients with symptomatic carotid artery stenosis: an international multicenter study. (17th May 2014)

• Record Type: Journal Article
• Authors: Tsivgoulis, G.; Krogias, C.; Georgiadis, G. S.; Mikulik, R.; Safouris, A.; Meves, S. H.; Voumvourakis, K.; Haršány, M.; Staffa, R.; Papageorgiou, S. G.; Katsanos, A. H.; Lazaris, A.; Mumme, A.; Lazarides, M.; Vasdekis, S. N.
• Is Part Of: European journal of neurology. Volume 21:Number 10(2014:Oct.)
• Page Start: 1251
• Page End: e76
• Publication Date: 2014-05-17
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.12461
• Languages: English
• ISSNs: 1351-5101

Abstract

<abstract abstract-type="main" id="ene12461-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ene12461-sec-0001" sec-type="section"> <title>Background and purpose</title> <p>Although the latest recommendations suggest that carotid endarterectomy (CEA) should be performed in symptomatic carotid artery stenosis (sCAS) patients within 2 weeks of the index event, only a minority of patients undergo surgery within the recommended time‐frame. The aim of this international multicenter study was to prospectively evaluate the safety of early CEA in patients with sCAS in everyday clinical practice settings.</p> </sec> <sec id="ene12461-sec-0002" sec-type="section"> <title>Methods</title> <p>Consecutive patients with non‐disabling acute ischaemic stroke (AIS) or transient ischaemic attack (TIA) due to sCAS (≥70%) underwent early (≤14 days) CEA at five tertiary‐care stroke centers during a 2‐year period. Primary outcome events included stroke, myocardial infarction (MI) or death occurring during the 30‐day follow‐up period and were defined according to the International Carotid Stenting Study criteria.</p> </sec> <sec id="ene12461-sec-0003" sec-type="section"> <title>Results</title> <p>A total of 165 patients with sCAS [mean age 69 ± 10 years; 69% men; 70% AIS; 6% crescendo TIA; 8% with contralateral internal carotid artery (ICA) occlusion] underwent early CEA (median elapsed time from symptom onset 8 days). Urgent CEA (≤2 days) was performed in 20 cases (12%). The primary outcomes of stroke and MI were 4.8% [95% confidence interval (CI) 1.5%–8.1%] and 0.6% (95% CI 0%–1.8%). The combined outcome event of non‐fatal stroke, non‐fatal MI or death was 5.5% (95% CI 2.0%–9.0%). Crescendo TIA, contralateral ICA occlusion and urgent CEA were not associated (<italic>P</italic> > 0.2) with a higher 30‐day stroke rate.</p> </sec> <sec id="ene12461-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Our findings indicate that the risk of early CEA in consecutive unselected patients with non‐disabling AIS or TIA due to sCAS is acceptable when the procedure is performed within 2 weeks (or even within 2 days) from symptom onset.</p> </sec> </abstract>