Meningothelial cells as part of the central nervous system host defence. (3rd June 2013)

• Record Type: Journal Article
• Authors: Li, Jia; Fang, Lei; Killer, Hanspeter E.; Flammer, Josef; Meyer, Peter; Neutzner, Albert
• Is Part Of: Biology of the cell. Volume 105:Number 7(2013:Jul.)
• Page Start: 304
• Page End: 315
• Publication Date: 2013-06-03
• Subjects: Cytology -- Periodicals; Electron microscopy -- Periodicals; 571.6
• DOI: 10.1111/boc.201300013
• Languages: English
• ISSNs: 0248-4900

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="boc201300013-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Meningothelial cells or MECs, the cellular component of the brain‐covering meninges, form the interface between neurons and the cerebrospinal fluid. Previously considered to be a passive barrier, MECs are now recognized to play a more active role under physiological and pathophysiological conditions in the brain. Here, MECs express the danger signal receptor TLR4 and are involved in immunological processes in the cerebrospinal fluid through the phagocytosis of bacteria. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh190vc4z3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>