First identification of Ewing's sarcoma‐derived extracellular vesicles and exploration of their biological and potential diagnostic implications. (4th May 2013) - Miller, Isabella V.
Abstract We report on the first identification of exosomes derived from Ewing's sarcoma cell lines, which contain specific transcripts including EWS‐FLI1 that are suitable for sensitive detection of ES exosomes in a pre‐clinical model for patient plasma. Microarray analysis revealed an exosomal transcriptional signature involved in G‐protein‐coupled signalling, neurotransmitter signalling and stemness.