Polygenic risk score and the psychosis continuum model. (25th June 2014)

• Record Type: Journal Article
• Authors: Tesli, M.; Espeseth, T.; Bettella, F.; Mattingsdal, M.; Aas, M.; Melle, I.; Djurovic, S.; Andreassen, O. A.
• Is Part Of: Acta psychiatrica Scandinavica. Volume 130:Number 4(2014:Oct.)
• Page Start: 311
• Page End: 317
• Publication Date: 2014-06-25
• Subjects: Psychiatry -- Periodicals; 616.89
• DOI: 10.1111/acps.12307
• Languages: English
• ISSNs: 0001-690X

Abstract

<abstract abstract-type="main" id="acps12307-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="acps12307-sec-0001" sec-type="section"> <title>Objective</title> <p>Schizophrenia (SZ) and bipolar disorder (BD) are heritable, polygenic disorders with shared clinical characteristics and genetic risk indicating a psychosis continuum. This is the first study using polygenic risk score (PGRS) to investigate the localization of diagnostic subcategories along the entire psychosis spectrum.</p> </sec> <sec id="acps12307-sec-0002" sec-type="section"> <title>Method</title> <p>Based on results from the Psychiatric Genomics Consortium (PGC), we assigned a SZ and BD PGRS to each individual in our independent sample [<italic>N</italic> = 570 BD spectrum cases, 452 SZ spectrum cases and 415 healthy controls (CTR)]. Potential differences in mean SZ and BD PGRS across diagnostic spectrums and subcategories were explored.</p> </sec> <sec id="acps12307-sec-0003" sec-type="section"> <title>Results</title> <p>SZ and BD PGRSs were significantly associated with both SZ and BD spectrums compared with CTR. For the subcategories, SZ PGRS was significantly associated with SZ, schizoaffective disorder, psychosis not otherwise specified, and BD1, while BD PGRS was significantly associated with BD1 and BD2. There were no significant differences between any of the diagnostic spectrums or subgroups for neither the SZ nor BD PGRS. Lifetime psychosis was significantly associated with SZ PGRS but not with BD PGRS.</p> </sec> <sec id="acps12307-sec-0004" sec-type="section"> <title>Conclusion</title> <p>These findings further support the psychosis continuum model and provide molecular polygenetic validation of the localization of diagnostic subcategories within this continuum.</p> </sec> </abstract>