Comprehensive Endometrial Immunoglobulin Subclass Analysis in Infertile Women Suffering from Repeated Implantation Failure with or without Chronic Endometritis. (5th June 2014)

• Record Type: Journal Article
• Authors: Kitaya, Kotaro; Tada, Yoshihiro; Hayashi, Terumi; Taguchi, Sagiri; Funabiki, Miyako; Nakamura, Yoshitaka
• Is Part Of: American journal of reproductive immunology. Volume 72:Number 4(2014:Oct.)
• Page Start: 386
• Page End: 391
• Publication Date: 2014-06-05
• Subjects: Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12277
• Languages: English
• ISSNs: 1046-7408

Abstract

<abstract abstract-type="main" id="aji12277-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="aji12277-sec-0001" sec-type="section"> <title>Problem</title> <p>Chronic endometritis (CE) is a local inflammatory condition with unusual plasmacyte infiltration in the endometrial stromal area. CE is frequently found in infertile women with repeated implantation failure (RIF). In this study, we comprehensively investigated the endometrial immunoglobulin (Ig) subclass expression in infertile women suffering from RIF with versus without CE.</p> </sec> <sec id="aji12277-sec-0002" sec-type="section"> <title>Method of study</title> <p>Endometrial biopsy specimens obtained from 28 infertile women with RIF and CE (the RIF‐CE group), 23 infertile women with RIF but without CE (the RIF‐non‐CE group), and 22 proven fertile women undergoing hysterectomy for benign endometrial pathology (the control group) were immunostained for Ig subclass expression.</p> </sec> <sec id="aji12277-sec-0003" sec-type="section"> <title>Results</title> <p>The density of IgM+, IgA<sub>1</sub>+, IgA<sub>2</sub>+, IgG<sub>1</sub>+, and IgG<sub>2</sub>+ stromal cells were significantly higher in the RIF‐CE group than that in the RIF‐non‐CE and control group. The density of IgG<sub>2</sub>+ stromal cells was significantly higher than that of any other Ig subclass‐positive cells (<italic>P</italic> < 0.045) in the RIF‐CE group. In serial section staining, the immunoreactivity for CD138 and Ig subclasses in the endometrial stroma was detectable in adjacent cells of some specimens in the RIF‐CE group.</p> </sec> <sec id="aji12277-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The endometrium of infertile women with RIF‐CE was characterized by increase in IgM, IgA, and IgG expression and predominance of IgG<sub>2</sub> over other Ig subclasses.</p> </sec> </abstract>