Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor1. Issue 38 (27th June 2014)

• Record Type: Journal Article
• Authors: Mikhaylov, G.; Klimpel, D.; Schaschke, N.; Mikac, U.; Vizovisek, M.; Fonovic, M.; Turk, V.; Turk, Boris; Vasiljeva, Olga
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 38(2014)
• Page Start: 10077
• Page End: 10081
• Publication Date: 2014-06-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201402305
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Cathepsin B (CtsB) is a lysosomal cysteine proteinase that is specifically translocated to the extracellular milieu during cancer progression. The development of a lipidated CtsB inhibitor incorporated into the envelope of a liposomal nanocarrier (LNC‐NS‐629) is described. Ex vivo and in vivo studies confirmed selective targeting and internalization of LNC‐NS‐629 by tumor and stromal cells, thus validating CtsB targeting as a highly promising approach to cancer diagnosis and treatment.</p> </abstract>