Hexacoordinate Nickel(II)/(III) Complexes that Mimic the Catalytic Cycle of Nickel Superoxide Dismutase1. Issue 38 (23rd July 2014)

• Record Type: Journal Article
• Authors: Chatterjee, Sudip K.; Maji, Ram Chandra; Barman, Suman Kumar; Olmstead, Marilyn M.; Patra, Apurba K.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 38(2014)
• Page Start: 10184
• Page End: 10189
• Publication Date: 2014-07-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201404133
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A functional model complex of nickel superoxide dismutase (NiSOD) with a non‐peptide ligand which mimics the full catalytic cycle of NiSOD is unknown. Similarly, it has not been fully elucidated whether NiSOD activity is a result of an outer‐ or inner‐sphere electron‐transfer mechanism. With this in mind, two octahedral nickel(II)/(III) complexes of a bis‐tridentate N₂S donor carboxamide ligand, <italic>N</italic>‐2‐phenylthiophenyl‐2′‐pyridinecarboxamide (HL^Ph), have been synthesized, structurally characterized, and their SOD activities examined. These complexes mimic the full catalytic cycle of NiSOD. Electrochemical experiments support an outer‐sphere electron‐transfer mechanism for their SOD activity.</p> </abstract>