A brief overview of amyloids and Alzheimer's disease. (30th July 2014)

• Record Type: Journal Article
• Authors: Ow, Sian‐Yang; Dunstan, Dave E.
• Is Part Of: Protein science. Volume 23:Number 10(2014:Oct.)
• Page Start: 1315
• Page End: 1331
• Publication Date: 2014-07-30
• Subjects: Proteins -- Periodicals; 572.6
• DOI: 10.1002/pro.2524
• Languages: English
• ISSNs: 0961-8368

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Amyloid fibrils are self‐assembled fibrous protein aggregates that are associated with a number of presently incurable diseases such as Alzheimer's and Parkinson's disease. Millions of people worldwide suffer from amyloid diseases. This review summarizes the unique cross‐β structure of amyloid fibrils, morphological variations, the kinetics of amyloid fibril formation, and the cytotoxic effects of these fibrils and oligomers. Alzheimer's disease is also explored as an example of an amyloid disease to show the various approaches to treat these amyloid diseases. Finally, this review investigates the nanotechnological and biological applications of amyloid fibrils; as well as a summary of the typical biological pathways involved in the disposal of amyloid fibrils and their precursors.</p> </abstract>